Drew Barrymore surprised fans by posting a throwback Instagram photo from filming the movie '50 First Dates' with her friend ...

Drew Barrymore reflected on turning 50 years old on February 22 and how she plans on celebrating with her daughters Frankie ...

Drew Barrymore was gifted custom cakes from her two daughters while A-list pals sent sweet messages as the star celebrated ...

Drew Barrymore revealed she and then-boyfriend Luke Wilson were once detained after being caught urinating in public at a ...

Drew Barrymore reflected on turning 50 years old on February 22 and how she plans on celebrating with her daughters Frankie ...

In his birthday message to Drew Barrymore, Adam Sandler made a reference to their beloved comedy, The Wedding Singer.

Drew Barrymore got candid about the time she got 'detained' and 'frisked' by while on a date night with her ex Luke Wilson.

It was emotional celebration when Drew Barrymore 's daughters surprised her on her talk show with multiple custom cakes in ...

Drew Barrymore burst into tears when reuniting with the Ward family — who looked after her as a child when she filmed ...

"It's like a distant memory that just doesn't seem like me, but it is me," Barrymore said years later while recalling the viral moment.

In PEOPLE's exclusive sneak peek at 'The Drew Barrymore Show' on Feb. 21, Drew Barrymore gets emotional when she's surprised with a meaningful gift from her daughters on her milestone 50th birthday ...