This affiliate content is not influenced by our advertising relationships, but AP and Data Skrive might earn commissions from our partners’ links in this content.

See all the player props bets with current odds for the MLB matchup between the Seattle Mariners and Astros on }{ day_of_week model.date }}, May 22,

Even if George Kirby is on a pitch count, he will do his part to help the Mariners win another big inter-division game against the rival Astros tonight. It’s a battle at the top of the AL West, as the Seattle Mariners are in Houston to open a four-game set against the Astros.

Cal Raleigh MLB - Seattle Mariners vs. Chicago White Sox - 05/21/2025 Chicago White Sox Seattle Mariners Major League Baseball

The Mariners pulled out a taut win over the White Sox on Wednesday, taking two games out of the three in Chicago ahead of a big series against the Astros.

Pregame analysis and predictions of the Seattle Mariners vs. Chicago White Sox MLB game to be played on May 21, 2025 on ESPN.