Ayatollah Ali Khamenei has spent almost four decades as Shi'ite Iran's supreme leader building a regional power to rival the Sunni states across the Gulf and implacably hostile to the U.S. and Israel - while crushing repeated unrest at home.

Iranian crown prince Reza Pahlavi claims the regime is at its weakest following Israeli strikes, stating it's only a matter of time before people overthrow the government.

Video shows what appeared to be the moment an Israeli missile hit the Islamic Republic of Iran News Network's studio in Tehran.

Military strikes between Iran and Israel have prompted concern about potential damage and disruption to the region's important oil and gas fields and infrastructure.

In the central Israeli city of Petah Tikva, many people seem to be lining up to support the military operation against Iran — despite an Iranian missile hitting here days ago.

The Kremlin responded Monday to remarks by Israeli Prime Minister Netanyahu on possible Iranian regime change, issuing a condemnation of the "actions" that have led to escalated tensions between the two Middle Eastern nations.

After Israel attacked Iran, the population has lamented the lack of adequate safety instructions and evacuation orders, turning to social media for answers.

Londoners with friends and family in Iran are only able to watch with concern from thousands of kilometres away as conflict continues to escalate between the country and Israel.