De Armas has been married once to the Spanish actor Marc Clotet from 2011 to 2013. The Cuban actress was only 22 when she tied the knot and it came well before her Hollywood breakthrough in the late 2010s. She dated Ben Affleck after meeting the actor while filming Deep Water in 2019. They are said to have split up in 2021.

Tom Cruise and Ana de Armas appeared to confirm their relationship as they were photographed holding hands in Vermont, after months of romance speculation