Iran activated its air defences in several regions on Saturday and Israel told its citizens to take shelter ahead of a fresh barrage of missiles, as the arch-foes exchanged massive strikes in their fiercest direct confrontation in history.

Shapiro served as Deputy Assistant Secretary of Defense for the Middle East until January—charged with, among other things, considering scenarios in which tensions between Israel and Iran escalated into all-out war and preparing U.

Fox News’ Alex Hogan and Mark Meredith report on the strikes between Israel and Iran, and reaction from the United States. Heritage Foundation senior fellow Brent Sadler joins ‘Fox News Live’ to analyze the future of Iran’s nuclear program.

Israel's Prime Minister Benjamin Netanyahu says his country will strike "every site and every target of the ayatollah regime" in Iran.

Trump told the Wall Street Journal that he knew all about Israel’s plan ahead of time, that he wasn’t given a mere “heads-up.”

Iranian officials have repeatedly denied seeking a nuclear weapon. The United States and Iran have held five rounds of negotiations toward achieving an agreement that would limit Iran's nuclear activities in exchange for sanctions relief, with a sixth round of talks scheduled for Sunday.

Israel warns "Tehran will burn" if Iran continues firing missiles, while state media say 60 people have been killed in a strike on Iran's capital.

National security experts warn that Israel's attack on Iran shows why Chinese land and asset purchases in the U.S. pose a significant threat to American security.