The exchange of fire comes as talks on Iran's nuclear program in Oman between the U.S. and Iran were called off.

Israeli emergency services have said at least two people were killed in the strikes and dozens of people are injured.

The Israeli Defence Forces (IDF) on Sunday claimed it hit Iranian Defence Ministry headquarters as well as the headquarters of its nuclear project. Iran, meanwhile, launched a fresh series of missiles against Israel,

Explore the timeline of tensions between Israel and Iran, from the 1960s to 2025. This explainer highlights the key events, including nuclear developments, military strikes and escalating hostilities between the two countries.

The Israeli Air Force (IAF) says it has destroyed "dozens" of radars and surface-to-air missile launchers as part of the attacks on Iran's air defence systems in the west of the country. Calling it a "large-scale strike", the IAF says this forms part of ongoing operations to damage Iran's air defence systems and those of its proxies.

Given the limited access international journalists have in Iran, the situation on the ground is largely unconfirmed.

Israel had earlier issued an evacuation warning to Iranians residing near weapons facilities in Iran, an Israeli military spokesperson said in a post on X in Arabic and Farsi. The spokesperson said the warning included all weapons factories and supporting facilities.

Israel and Iran have opened a new chapter in their long history of conflict. Israel launched a major attack with strikes early Friday that set off explosions in the Iranian capital of Tehran.